Figure 5. Comparison of coiled-coil domains of human and rat macrogolgin/giantin. The probability for the formation of coiled-coils is calculated by the COILS program (Lupas et al., 1991). A transmembrane (TM) hydrophobic region at the C-terminus is postulated to be responsible for anchoring giantin to Golgi membrane with much of the molecule extending to the cytoplasm.
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