|
| Table 1. Extent of conversion of Candida rugosa lipase-catalyzed esterification of ibuprofen at 48 hrs under various conditions. |
Ibuprofen Concentration |
60 mM |
48 mM |
36 mM |
24 mM |
|
Isooctane |
aw = 0.73 |
0.29 ± 0.01 |
0.23 ± 0.01 |
0.29 ± 0.01 |
0.27 ± 0.02 |
aw = 0.59 |
0.20 ± 0.01 |
0.21 ± 0.01 |
0.23 ± 0.01 |
0.24 ± 0.01 |
|
aw = 0.43 |
0.06 ± 0.01 |
0.06 ± 0.01 |
0.03 ± 0.02 |
0.03 ± 0.01 |
|
2,5-Dimethylhexane |
aw = 0.73 |
0.17 ± 0.04 |
0.12 ± 0.01 |
0.07 ± 0.01 |
ND |
aw = 0.59 |
0.11 ± 0.01 |
0.09 ± 0.01 |
0.07 ± 0.01 |
ND |
|
aw = 0.43 |
NR |
NR |
NR |
ND |
|
2-Methylheptane |
aw = 0.73 |
0.28 ± 0.01 |
0.25 ± 0.01 |
0.24 ± 0.01 |
0.24 ± 0.01 |
aw = 0.59 |
0.24 ± 0.01 |
0.21 ± 0.01 |
0.18 ± 0.01 |
0.23 ± 0.01 |
|
aw = 0.43 |
0.13 ± 0.002 |
0.056 ± 0.002 |
0.028 ± 0.002 |
NR |
|
n-Octane |
aw = 0.73 |
0.26 ± 0.01 |
0.22 ± 0.05 |
0.21 ± 0.01 |
0.22 ± 0.01 |
aw = 0.59 |
0.24 ± 0.01 |
0.17 ± 0.01 |
0.18 ± 0.01 |
0.25 ± 0.01 |
|
aw = 0.43 |
0.074 ± 0.005 |
0.066 ± 0.008 |
0.086 ± 0.015 |
0.189 ± 0.001 |
|
ND: indicates the reaction was not performed. |
|
|