|
| Table 3. Enantiomeric excess of the substrate at 48 hrs revealing little effect from initial ibuprofen concentration, but influences of both water activity and solvent. |
Ibuprofen Concentration |
60 mM |
48 mM |
36 mM |
24 mM |
|
Isooctane |
aw = 0.73 |
0.442 ± 0.0127 |
0.402 ± 0.0126 |
0.419 ± 0.0053 |
0.462 ± 0.0074 |
aw = 0.59 |
0.343 ± 0.0101 |
0.330 ± 0.0088 |
0.313 ± 0.0019 |
0.303 ± 0.0093 |
|
aw = 0.43 |
0.0852 ± 0.0001 |
0.0783 ± 0.0061 |
0.0818 ± 0.0001 |
0.0907 ± 0.0045 |
|
2,5-Dimethylhexane |
aw = 0.73 |
0.247 ± 0.0078 |
0.201 ± 0.0029 |
0.161 ± 0.0067 |
ND |
aw = 0.59 |
0.118 ± 0.0056 |
0.104 ± 0.0011 |
0.0836 ± 0.0046 |
ND |
|
aw = 0.43 |
NR |
NR |
NR |
ND |
|
2-Methylheptane |
aw = 0.73 |
0.396 ± 0.0023 |
0.385 ± 0.0045 |
0.380 ± 0.0056 |
0.378 ± 0.0011 |
aw = 0.59 |
0.361 ± 0.0010 |
0.318 ± 0.0026 |
0.303 ± 0.0070 |
0.286 ± 0.0064 |
|
aw = 0.43 |
0.042 ± 0.0022 |
0.068 ± 0.0077 |
0.028 ± 0.0017 |
NR |
|
n-Octane |
aw = 0.73 |
0.300 ± 0.0065 |
0.279 ± 0.0001 |
0.250 ± 0.0065 |
0.300 ± 0.0040 |
aw = 0.59 |
0.215 ± 0.0022 |
0.224 ± 0.0071 |
0.182 ± 0.0011 |
0.185 ± 0.0042 |
|
aw = 0.43 |
0.014 ± 0.0003 |
0.026 ± 0.0067 |
0.037 ± 0.0093 |
0.037 ± 0.0007 |
|
ND:
indicates the reaction was not performed. |
|
|