|
| Table 1. Oxidative kinetic resolution of 1, with resting cells. |
Substrate:dry
cells |
Reaction time (hrs) |
Enantiomeric ratio R/S |
Ketone/Alcohol |
1:3 |
36 |
56/44 |
10/90 |
48 |
57/43 |
10/90 |
|
60 |
56/44 |
10/90 |
|
72 |
56/44 |
8/92 |
|
1:9 |
24 |
67/33 |
19/81 |
48 |
68/32 |
28/72 |
|
72 |
72/28 |
37/63 |
|
1:18 |
36 |
93/7 |
56/44 |
48 |
65/35 |
47/53 |
|
60 |
66/34 |
23/77 |
|
|
|