|
| Table 2. Oxidative kinetic resolution of 1, in the 3-L bioreactor. |
Substrate:dry
cells |
Reaction time (hrs) |
Enantiomeric ratio R/S |
Ketone/Alcohol |
1:5 |
0 |
53/47 |
6/94 |
19 |
61/39 |
13/87 |
|
21 |
67/33 |
9/91 |
|
22 |
73/27 |
8/92 |
|
23 |
67/33 |
8/92 |
|
24 |
56/44 |
13/87 |
|
|