Figure 2. M. tamulus sPLA₂ amino acid sequence alignment.
(a) Sequence alignment with imperatoxin I from Pandinus imperator. By analogy with imperatoxin I, MtsPLA₂ comprises of (1) signal sequence; (2) large enzymatic sub-unit; (3) pentameric connecting peptide; (4) small sub-unit.
(b) Sequence alignment with other group III sPLA₂s from Drosophila melanogaster, Homo sapiens, Heloderma suspectum and Apis mellifera. The Ca²⁺ binding loop and active site motifs are shown in boxes, the conserved residues and the cysteines are shown in bold. Hyphens are used to maximize the alignment and dots denote the end of the sequence. Numbers at the end of the sequences denote the percent homology to MtsPLA_2.