Table 1 - Artificial neural network modeling studies to predict the yield of enzymatic synthesis of betulinic acid ester

Table 1. Experimental values (training, testing and validation data), actual and model predicated of isolated yield on the enzymatic reaction.

Run No.	Time (h)	Temperature (ºC)	Amount of Enzyme (mg)	Molar ratio¹	Isolated Yield (%)
Run No.	Time (h)	Temperature (ºC)	Amount of Enzyme (mg)	Molar ratio¹	Actual	predicted
Training Data
1	8	50	150	0.6	33.3	33.28
2	24	50	150	0.6	58.8	58.85
3	16	40	150	0.6	31.1	31.11
4	16	50	50	0.6	39.8	39.78
5	16	50	250	0.6	43.1	43.15
6	16	50	150	0.2	29.5	29.51
7	12	45	100	0.4	20.2	20.24
8	20	45	100	0.4	36.5	36.49
9	20	55	100	0.4	47.4	47.39
10	12	45	200	0.4	27.6	27.57
11	20	45	200	0.4	43.2	43.15
12	12	45	100	0.8	35.6	35.58
13	20	45	100	0.8	49.1	49.11
14	12	55	100	0.8	55.2	55.22
15	12	45	200	0.8	40.8	40.81
16	20	45	200	0.8	58.6	58.54
17	12	55	200	0.8	52.5	52.44
18	20	55	100	0.8	62.7	62.64
19	16	60	150	0.6	53.3	53.3
20	16	50	150	1.0	58.9	58.94
21	16	50	150	0.6	54.7	54.57

Testing Data
22	20	55	200	0.4	46.4	46.69
23	12	55	100	0.4	36.2	35.32
24	12	55	200	0.4	35.4	36.2
25	20	55	200	0.8	60.4	60.12

Validation Data
26	24	45	176	1.0	57.5	58.11
27	24	50	176	1.0	60.5	60.23
28	24	55	176	1.0	61.8	61.34
29	24	60	176	1.0	57.3	58.12
30	20	53	148	0.8	64.3	64.91
31	20	54	145	0.9	64.7	65.65

¹Molar ratio = mmol betulinic acid/mmol phthalic anhydride

Supported by UNESCO / MIRCEN network

Home | Mail to Editor | Search | Archive