Table 3. Comet assay of genomic DNA in KB cells untreated and treated with compound 3 at different concentrations for 72 hrs. Stock solution of compounds was prepared in DMSO and the final concentration of this solvent was kept constant at 0.25%. Control cultures received DMSO alone. |
Treatments |
KB cells |
Control |
93 ± 3.4 |
Compound
3 |
1096 ± 18* |
12.5 µM |
1320 ± 36* |
25 µM |
2765 ± 31* |
aTMOM= tail moment expressed as the product of TD (distance between head and tail) and TDNA. The values are the mean ± SD of three experiments performed in quadruplicate. *Significant vs. control untreated cells (p < 0.001). |
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