Table
1. Hematological variables measured at baseline (day 10) and
after VEGF121 gene therapy (days 20 and 40). |
Hematological variables |
Control |
pVEGF121 |
Physiological valuesa |
||||
day 10 |
day 20 |
day 40 |
day 10 |
day 20 |
day 40 |
||
Hemoglobin (g/L) |
12.3±1.5 |
13.6±2.2 |
13.8±2.9 |
12.2±2.0 |
11.3±1.0 |
13.0±2.5 |
11.0-12.5 |
Hematocrit (%/vol) |
40±5 |
44±7 |
45±5 |
37±4 |
38±3 |
41±2 |
38-40 |
Glycemia (mmol/L) |
4.4±1.8 |
4.4±0.8 |
4.2±0.7 |
4.3±1.3 |
4.4±0.4 |
4.1±0.4 |
4-6 |
Creatinin (mmol/L) |
74±14 |
82±16 |
96±6 |
72±7 |
89±11 |
93±8 |
50-100 |
Total proteins (g/L) |
61.8±10.5 |
68.2±7.2 |
65.9±4.8 |
66.7±5.9 |
70.4±3.7 |
64.6±4.2 |
40-70 |
Albumin (g/L) |
36.1±15.2 |
34.1±5.7 |
34.9±2.9 |
33.0±5.7 |
32.0±5.5 |
32.9±4.3 |
30-60 |
AP (U/L) |
108±30 |
128±26 |
137±32 |
92±26 |
122±18 |
138±27 |
80-180 |
GPT (U/L) |
25±11 |
27±4 |
31±10 |
17±3 |
27±10 |
34±5 |
2-40 |
GOT (U/L) |
5.4±3.2 |
8.1±1.8 |
8.6±1.5 |
5.8±1.2 |
6.6±2.0 |
8.2±2.3 |
5-10 |
Coagulation time (min) |
5.7±1.7 |
9.1±8.9 |
13.3±13.0 |
5.6±1.4 |
5.7±1.8 |
5.3±1.0 |
4-8 |
Bleeding time (min) |
1.2±0.2 |
1.1±0.2 |
1.4±0.3 |
1.3±0.4 |
1.1±0.2 |
1.3±0.4 |
1-3 |
Platelet counting (x109) |
163±41 |
198±41 |
194±40 |
199±41 |
193±47 |
185±54 |
130-200 |
a(Tvedten,
1981) |
|